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The effects of intravenous diazepam and hyoscine upon recognition memory

Richardson, J. T. E.; Frith, C. D.; Scott, E.; Crow, T. J. and Cunningham-Owens, D. (1984). The effects of intravenous diazepam and hyoscine upon recognition memory. Behavioural Brain Research, 14(3) pp. 193–199.

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Diazepam and hyoscine are known to have amnesic effects when administered intravenously. Nevertheless, they achieve these effects by entirely different neurochemical mechanisms, and so the question arises whether they can be differentiated in terms of their effects upon different categories of encoding operations. Sixteen normal volunteers received intravenous administrations of diazepam, hyoscine, and saline following a double-blind procedure. Both drugs completely eliminated the subjects' ability to discriminate between successive lists of words in a test of recognition memory. Moreover, both drugs also impaired the subjects' ability to reject homophones or synonyms of presented words. Thus, both diazepam and hyoscine appeared to impair the use of list tags, phonemic coding, and semantic coding in storing individual stimulus items in long-term memory.

Item Type: Journal Item
ISSN: 1872-7549
Academic Unit/School: Learning and Teaching Innovation (LTI) > Institute of Educational Technology (IET)
Learning and Teaching Innovation (LTI)
Research Group: Centre for Research in Education and Educational Technology (CREET)
Item ID: 49784
Depositing User: John T. E. Richardson
Date Deposited: 29 Jun 2017 12:51
Last Modified: 07 Dec 2018 10:52
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