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A potential method for comparing instrumental analysis of volatile organic compounds using standards calibrated for the gas phase

Lourenco, Celia; González-Méndez, Ramón; Reich, Fraser; Mason, Nigel and Turner, Claire (2017). A potential method for comparing instrumental analysis of volatile organic compounds using standards calibrated for the gas phase. International Journal of Mass Spectrometry (Early Access).

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DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.ijms.2017.05.011
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Abstract

In this paper we report a method for the comparative analysis of volatile organic compounds (VOCs) at physiologically representative concentrations by different analytical methods Standard aqueous solutions of acetone, ethanol, methanol, 1-propanol, 2-propanol and acetaldehyde were prepared by adding a specific mass of compound to a known volume of water, calculated using published Henry’s law constants for individual compounds. Headspace concentrations are thus known from established partitioning from dilute aqueous phase in accordance with Henry’s law. Selected Ion Flow Tube Mass Spectrometry (SIFT-MS), Proton Transfer Reaction Mass Spectrometry (PTR-MS), and Gas Chromatography–Mass Spectrometry (GC–MS) coupled to thermal desorption have been used to study and evaluate the performance of the instruments in the analysis of these VOCs. These analytical techniques have been widely used in the identification and quantification of trace concentrations of VOCs in biological samples. Quantitative determination of VOC concentration was achieved and the performance of the instruments compared with one another. Calibration curves are given within the range 101–103 ppbv.

Item Type: Journal Item
Copyright Holders: 2017 Elsevier
ISSN: 1387-3806
Project Funding Details:
Funded Project NameProject IDFunding Body
PIMMS-Proton Ionization Molecular Mass287382EU; Marie Curie
Keywords: Trace gas analysis; SIFT-MS; PTR-MS; GC–MS; Selected ion flow tube mass spectrometry; Proton transfer reaction mass spectrometry
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Innovation, Knowledge & Development research centre (IKD)
Item ID: 49644
Depositing User: Claire Turner
Date Deposited: 15 Jun 2017 15:43
Last Modified: 15 Jun 2017 15:43
URI: http://oro.open.ac.uk/id/eprint/49644
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