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Accumbal cholinergic interneurons differentially influence motivation related to satiety signaling

Aitta-aho, Teemu; Phillips, Benjamin U.; Pappa, Elpiniki; Hay, Y. Audrey; Harnischfeger, Fiona; Heath, Christopher J.; Saksida, Lisa M.; Bussey, Timothy J. and Apergis-Schoute, John (2017). Accumbal cholinergic interneurons differentially influence motivation related to satiety signaling. eNeuro, 4(2)

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Satiety, rather than all or none, can instead be viewed as a cumulative decrease in the drive to eat that develops over the course of a meal. The nucleus accumbens (NAc) is known to play a critical role in this type of value reappraisal, but the underlying circuits that influence such processes are unclear. Although NAc cholinergic interneurons (CINs) comprise only a small proportion of NAc neurons, their local impact on reward-based processes provides a candidate cell population for investigating the neural underpinnings of satiety. The present research therefore aimed to determine the role of NAc-CINs in motivation for food reinforcers in relation to satiety signaling. Through bi-directional control of CIN activity in mice we show that when motivated by food restriction, increasing CIN activity led to a reduction in palatable food consumption while reducing CIN excitability enhanced food intake. These activity-dependent changes only developed late in the session and were unlikely to be driven by the innate reinforcer strength, suggesting that CIN modulation was instead impacting the cumulative change in motivation underlying satiety signaling. We propose that on a circuit-level, an overall increase in inhibitory tone onto NAc output neurons played a role in the behavioral results, as activating NAc-CINs led to an inhibition of medium spiny neurons that was dependent on nicotinic receptor activation. Our results reveal an important role for NAc-CINs in controlling motivation for food intake and additionally provide a circuit-level framework for investigating the endogenous cholinergic circuits that signal satiety.

Item Type: Journal Item
Copyright Holders: 2017 The Authors
ISSN: 2373-2822
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Health and Wellbeing PRA (Priority Research Area)
Item ID: 49151
Depositing User: Christopher Heath
Date Deposited: 11 Apr 2017 14:46
Last Modified: 23 Jan 2020 18:12
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