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Nanoparticle functionalized laser patterned substrate: an innovative route towards low cost biomimetic platforms

Bagga, K.; McCann, R.; O'Sullivan, F.; Ghosh, P.; Krishnamurthy, S.; Stalcup, A.; Vázquez, M. and Brabazon, D. (2017). Nanoparticle functionalized laser patterned substrate: an innovative route towards low cost biomimetic platforms. RSC Advances, 7 pp. 8060–8069.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1039/C6RA27260F
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Abstract

Integration of nanotechnology and advanced manufacturing processes presents an attractive route to produce devices for adaptive biomedical device technologies. However, tailoring biological, physical, and chemical properties often leads to complex processing steps and therefore to high manufacturing cost impeding further scalability. Herein, a novel laser-based approach is introduced to manufacture low cost biocompatible polymer substrates functionalized with ultrapure nanoparticles. Laser direct writing was performed to create micron-sized patterns on 188 μm-thick cyclic olefin polymer (COP) substrates using a picosecond pulsed 1064 nm Nd:YAG laser. The Pulsed Laser Ablation in Liquids (PLAL) technique was exploited in this work to prepare colloidal solutions of ultrapure nanoparticles to impart bio-functionality onto laser patterned surfaces. Combining the laser patterns and their modification with PLAL-nanoparticles resulted in a functional and biocompatible substrate for biosensing applications. Our in vitro cell viability studies using a model cell line (human skin keratinocyte, HaCaT) suggest that these nanoparticles immobilized on the surfaces function as a biomimetic platform with the ability to interact with different biological entities (e.g. DNA, antibodies etc.).

Item Type: Journal Item
Copyright Holders: 2017 Royal Society of Chemistry
ISSN: 2046-2069
Project Funding Details:
Funded Project NameProject IDFunding Body
Dye sensitised solar cells with functionalised graphene nanosheets. (XD-13-064-SK)Not SetUKIERI (UK-India Education and Research Initiative)
Marie Sklodowska-Curie grant655194European Union
Not Set12/IA/1576Science Foundation Ireland (SFI)
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 48931
Depositing User: Satheesh Krishnamurthy
Date Deposited: 15 Mar 2017 11:38
Last Modified: 16 Mar 2017 13:33
URI: http://oro.open.ac.uk/id/eprint/48931
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