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Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids

Golding, J. P.; Kemp-Symonds, J. G. and Dobson, J. M. (2017). Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids. Veterinary and Comparative Oncology (Early Access).

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DOI (Digital Object Identifier) Link: https://doi.org/10.1111/vco.12299
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Abstract

Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to lesions thicker than around 2 mm, and by the intrinsic antioxidant defences of tumour cells. We have developed a new PDT technique that combines an efficient transdermal penetration enhancer solution, for topical delivery of 5-aminolevulinic acid (ALA) photosensitiser, with acute topical post-PDT application of the glycolysis inhibitor lonidamine. We show that the new PDT combination treatment selectively kills sarcoid cells in vitro, with repeated rounds of treatment increasing sarcoid sensitisation to PDT. In vivo, ALA PDT followed by 600 μM lonidamine substantially improves treatment outcomes for occult, verrucous, nodular and fibroblastic sarcoids after 1 month (93% treatment response in 27 sarcoids), compared with PDT using only ALA (14% treatment response in 7 sarcoids).

Item Type: Journal Item
Copyright Holders: 2017 John Wiley & Sons Ltd
ISSN: 1476-5829
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetEuropean Society for Veterinary Dermatology
Keywords: combination therapy; glycolysis inhibition; PDT ; sarcoid; skin; tumour
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 48300
Depositing User: Jon Golding
Date Deposited: 31 Jan 2017 15:22
Last Modified: 11 Sep 2017 08:02
URI: http://oro.open.ac.uk/id/eprint/48300
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