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Golding, J. P.; Kemp-Symonds, J. G. and Dobson, J. M.
(2017).
DOI: https://doi.org/10.1111/vco.12299
Abstract
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to lesions thicker than around 2 mm, and by the intrinsic antioxidant defences of tumour cells. We have developed a new PDT technique that combines an efficient transdermal penetration enhancer solution, for topical delivery of 5-aminolevulinic acid (ALA) photosensitiser, with acute topical post-PDT application of the glycolysis inhibitor lonidamine. We show that the new PDT combination treatment selectively kills sarcoid cells in vitro, with repeated rounds of treatment increasing sarcoid sensitisation to PDT. In vivo, ALA PDT followed by 600 μM lonidamine substantially improves treatment outcomes for occult, verrucous, nodular and fibroblastic sarcoids after 1 month (93% treatment response in 27 sarcoids), compared with PDT using only ALA (14% treatment response in 7 sarcoids).
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About
- Item ORO ID
- 48300
- Item Type
- Journal Item
- ISSN
- 1476-5829
- Project Funding Details
-
Funded Project Name Project ID Funding Body Not Set Not Set European Society for Veterinary Dermatology - Keywords
- combination therapy; glycolysis inhibition; PDT ; sarcoid; skin; tumour
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Research Group
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Cancer Research Group - Copyright Holders
- © 2017 John Wiley & Sons Ltd
- Depositing User
- Jon Golding