The Open UniversitySkip to content
 

Gold nanoparticles for cancer radiotherapy: a review

Haume, Kaspar; Rosa, Soraia; Grellet, Sophie; Śmiałek, Małgorzata; Butterworth, Karl T.; Solov'yov, Andrey V.; Prise, Kevin M.; Golding, Jon and Mason, Nigel J. (2016). Gold nanoparticles for cancer radiotherapy: a review. Cancer Nanotechnology, 7(8)

Full text available as:
[img]
Preview
PDF (Version of Record) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB) | Preview
DOI (Digital Object Identifier) Link: https://doi.org/10.1186/s12645-016-0021-x
Google Scholar: Look up in Google Scholar

Abstract

Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can adversely affect healthy tissue outside the tumour volume, especially in the case of photon radiation (gamma and X-rays). Improved radiotherapy outcomes can be achieved by employing ion beams due to the characteristic energy deposition curve which culminates in a localised, high radiation dose (in form of a Bragg peak). In addition to ion radiotherapy, novel sensitisers, such as nanoparticles, have shown to locally increase the damaging effect of both photon and ion radiation, when both are applied to the tumour area. Amongst the available nanoparticle systems, gold nanoparticles have become particularly popular due to several advantages: biocompatibility, well-established methods for synthesis in a wide range of sizes, and the possibility of coating of their surface with a large number of different molecules to provide partial control of, for example, surface charge or interaction with serum proteins. This gives a full range of options for design parameter combinations, in which the optimal choice is not always clear, partially due to a lack of understanding of many processes that take place upon irradiation of such complicated systems. In this review, we summarise the mechanisms of action of radiation therapy with photons and ions in the presence and absence of nanoparticles, as well as the influence of some of the core and coating design parameters of nanoparticles on their radiosensitisation capabilities.

Item Type: Journal Item
Copyright Holders: 2016 The Authors
ISSN: 1868-6966
Project Funding Details:
Funded Project NameProject IDFunding Body
ARGENT Extension Advanced Radiotherapy, Generated By Exploiting Nanoprocesses And Technologies SUBSET-OF_SP-12-149-NM AMS 28012Not SetEC (European Commission): FP (inc.Horizon2020 & ERC schemes)
Keywords: gold nanoparticles; nanomedicine; radiosensitisation
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Item ID: 47828
Depositing User: Jon Golding
Date Deposited: 16 Nov 2016 10:09
Last Modified: 03 Feb 2017 13:20
URI: http://oro.open.ac.uk/id/eprint/47828
Share this page:

Altmetrics

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU