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Gold nanoparticles for imaging and drug transport to the CNS

Male, David; Gromnicova, Radka and Mcquaid, Conor (2016). Gold nanoparticles for imaging and drug transport to the CNS. In: Al-Jamal, Khuloud ed. Nanotechnology and the Brain. International Review of Neurobiology (130). London: Elsevier, pp. 155–189.

URL: http://www.sciencedirect.com/science/article/pii/S...
DOI (Digital Object Identifier) Link: https://doi.org/10.1016/bs.irn.2016.05.003
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Abstract

Gold nanoparticles with a core size of 2 nm covalently coated with glycans to maintain solubility, targeting molecules for brain endothelium, and cargo molecules hold great potential for delivery of therapies into the CNS. They have low toxicity, pass through brain endothelium in vitro and in vivo, and move rapidly through the brain parenchyma. Within minutes of infusion the nanoparticles can be detected in neurons and glia. These nanoparticles are relatively easy to synthesize in association with their surface ligands. They can be detected by electron microscopy, ICP-mass spectrometry, and spectroscopy.
However, modification of the basic gold nanoparticle is required for in vivo imaging by MR or radioactive methods. Depending on their surface coat, the nanoparticles
cross the brain endothelium by the plasma membrane/cytosolic route (passive transport) or by vesicular transcytosis (active transport). A primary aim of current research is to improve the biodistribution of the nanoparticles for CNS drug delivery. Smaller gold
nanoparticles are removed rapidly via the kidney, while larger nanoparticles are taken up by mononuclear phagocytes in various tissues. Receptors selectively located on brain endothelium can act as targets for the nanoparticles, to increase their delivery to the brain.

Item Type: Book Section
Copyright Holders: 2016 Elsevier
ISBN: 0-12-804636-8, 978-0-12-804636-4
Keywords: Gold nanoparticles, brain endothelium, central nervous system, nanocarriers, transcytosis.
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Innovation, Knowledge & Development research centre (IKD)
Biomedical Research Network (BRN)
Item ID: 47599
Depositing User: David Male
Date Deposited: 02 Nov 2016 17:22
Last Modified: 02 Nov 2016 17:23
URI: http://oro.open.ac.uk/id/eprint/47599
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