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Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets

Alyami, Hamad; Koner, Jasdip; Dahmash, Eman Z.; Bowen, James; Terry, David and Mohammed, Afzal R. (2017). Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets. Journal of Pharmacy and Pharmacology, 69(7) pp. 807–822.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1111/jphp.12623
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Abstract

Objectives: The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs).

Methods: The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macro-property assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing.

Key findings: The results showed that MCC demonstrated its best flowability at a moisture content of 11.2% w/w when compared to control, comprising of3.9% w/w moisture. The use of the composite powder coating process (without air) resulted in up to 80% increase in tablet hardness, when compared to the control. The study also demonstrated that surface adsorbed moisture can be displaced upon addition of excipients during dry processing circumventing the need for particle drying before tabletting.

Conclusions: It was concluded that MCC with a moisture content of 11% w/w provides a good balance between powder flowability and favourable ODT characteristics.

Item Type: Journal Item
Copyright Holders: 2016 Royal Pharmaceutical Society
ISSN: 2042-7158
Keywords: composite; disintegration; flowability; hardness; nano-indentation
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 47563
Depositing User: James Bowen
Date Deposited: 10 Oct 2016 09:38
Last Modified: 19 Jun 2017 09:12
URI: http://oro.open.ac.uk/id/eprint/47563
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