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Differences in microbial metabolites in urine headspace of subjects with Immune Thrombocytopenia (ITP) detected by volatile organic compound (VOC) analysis and metabolomics

Batty, Claire A.; Cauchi, Michael; Hunter, J. O.; Woolner, Jenny; Baglin, Trevor and Turner, Claire (2016). Differences in microbial metabolites in urine headspace of subjects with Immune Thrombocytopenia (ITP) detected by volatile organic compound (VOC) analysis and metabolomics. Clinica Chimica Acta, 461 pp. 61–68.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.cca.2016.07.021
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Abstract

ITP is an organ-specific autoimmune disorder characterised by a low platelet count whose cause is uncertain. A possible factor is food intolerance, although much of the information linking this with ITP is anecdotal. The role of food intolerance in ITP was studied by replacing a normal diet with an elemental diet (E028), but this did not increase platelet counts. Clear differences, however, were apparent between the volatile organic compounds (VOCs) in the urine headspace of patients with ITP and those present in healthy volunteers, which leads to speculation that abnormal metabolic activity of the intestinal microbiome may be a factor causing ITP. However, further work is needed to confirm this. There were also differences between the VOCs of patients on a normal diet and those on the elemental diet, and in this case, the VOCs involved are very likely to be of bacterial origin, as their production is affected by dietary manipulation. Many of these VOCs are known to be toxic.

Item Type: Journal Item
Copyright Holders: 2016 Elsevier B.V.
ISSN: 0009-8981
Project Funding Details:
Funded Project NameProject IDFunding Body
Is food intolerance a factor causing ITP? (SC-10-184-CT)Not SetThe ITP Support Association
Keywords: Immune Thrombocytopenia; ITP; metabolomics; volatile organic compounds; VOCs; selective ion flow tube mass spectrometry; (SIFT-MS)
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Innovation, Knowledge & Development research centre (IKD)
Item ID: 47537
Depositing User: Claire Turner
Date Deposited: 05 Oct 2016 11:20
Last Modified: 28 Jul 2017 00:00
URI: http://oro.open.ac.uk/id/eprint/47537
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