NMR studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified nucleosides

Zhang, Xiao-Hui and Xu, Yao-Zhong (2016). NMR studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified nucleosides. Magnetic Resonance in Chemistry, 54(11) pp. 887–892.

DOI: https://doi.org/10.1002/mrc.4501

Abstract

Systematic NMR characterization of 4-thio-5-furan-pyrimidine nucleosides or 4-thio-5-thiophene-pyrimidine nucleosides (ribonucleosides and 2′-deoxynucleosides) was performed. All proton and carbon signals of 4-thio-5-thiophene-ribouridine and related analogues were unambiguously assigned. The orientations of the base (4-thiouridine or its deoxy analogue) relative to the ring (furan or thiophene) are explored by a NMR approach and further supported by X-ray crystallographic studies. The procedures presented here would be applicable to other modified nucleosides and nucleotides.

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About

• Item ORO ID
• 47278
• Item Type
• Journal Item
• ISSN
• 0749-1581
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Science-Technology Plan Projects	2014E12SF074	Dalian Government
  Science-Technology Plan Projects	KJCX-ZTPY-2014-0009	Dalian Jinzhou New Area Government
  Project of Science Enterprise Investigation in Liaoning province of China (2015)	Not Set	Public welfare foundation

• Keywords
• 13C;1H; 4-thiothymidine; 5-ringed nucleoside; 5-thiophene-4-thiouridine; 5-furan-4-thiouridine; modified nucleoside; DNA; X-ray
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Research Group
• Chemistry and Materials Research Group
• Copyright Holders
• © 2016 John Wiley & Sons Ltd
• Depositing User
• Yao Xu