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Zhang, Xiao-Hui and Xu, Yao-Zhong
(2016).
DOI: https://doi.org/10.1002/mrc.4501
Abstract
Systematic NMR characterization of 4-thio-5-furan-pyrimidine nucleosides or 4-thio-5-thiophene-pyrimidine nucleosides (ribonucleosides and 2′-deoxynucleosides) was performed. All proton and carbon signals of 4-thio-5-thiophene-ribouridine and related analogues were unambiguously assigned. The orientations of the base (4-thiouridine or its deoxy analogue) relative to the ring (furan or thiophene) are explored by a NMR approach and further supported by X-ray crystallographic studies. The procedures presented here would be applicable to other modified nucleosides and nucleotides.
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About
- Item ORO ID
- 47278
- Item Type
- Journal Item
- ISSN
- 0749-1581
- Project Funding Details
-
Funded Project Name Project ID Funding Body Science-Technology Plan Projects 2014E12SF074 Dalian Government Science-Technology Plan Projects KJCX-ZTPY-2014-0009 Dalian Jinzhou New Area Government Project of Science Enterprise Investigation in Liaoning province of China (2015) Not Set Public welfare foundation - Keywords
- 13C;1H; 4-thiothymidine; 5-ringed nucleoside; 5-thiophene-4-thiouridine; 5-furan-4-thiouridine; modified nucleoside; DNA; X-ray
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Research Group
- Chemistry and Materials Research Group
- Copyright Holders
- © 2016 John Wiley & Sons Ltd
- Depositing User
- Yao Xu