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NMR studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified nucleosides

Zhang, Xiao-Hui and Xu, Yao-Zhong (2016). NMR studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified nucleosides. Magnetic Resonance in Chemistry, 54(11) pp. 887–892.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1002/mrc.4501
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Abstract

Systematic NMR characterization of 4-thio-5-furan-pyrimidine nucleosides or 4-thio-5-thiophene-pyrimidine nucleosides (ribonucleosides and 2′-deoxynucleosides) was performed. All proton and carbon signals of 4-thio-5-thiophene-ribouridine and related analogues were unambiguously assigned. The orientations of the base (4-thiouridine or its deoxy analogue) relative to the ring (furan or thiophene) are explored by a NMR approach and further supported by X-ray crystallographic studies. The procedures presented here would be applicable to other modified nucleosides and nucleotides.

Item Type: Journal Item
Copyright Holders: 2016 John Wiley & Sons Ltd
ISSN: 0749-1581
Project Funding Details:
Funded Project NameProject IDFunding Body
Science-Technology Plan Projects2014E12SF074Dalian Government
Science-Technology Plan ProjectsKJCX-ZTPY-2014-0009Dalian Jinzhou New Area Government
Project of Science Enterprise Investigation in Liaoning province of China (2015)Not SetPublic welfare foundation
Keywords: 13C;1H; 4-thiothymidine; 5-ringed nucleoside; 5-thiophene-4-thiouridine; 5-furan-4-thiouridine; modified nucleoside; DNA; X-ray
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 47278
Depositing User: Yao Xu
Date Deposited: 09 Sep 2016 14:24
Last Modified: 15 Sep 2017 11:01
URI: http://oro.open.ac.uk/id/eprint/47278
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