The Open UniversitySkip to content

UVA Assisted 4-Thiothymidine for Cancer Treatment

Ge, Jiang; Feng, Luo; Yaozhong, Xu and Xiaohui, Zhang (2016). UVA Assisted 4-Thiothymidine for Cancer Treatment. Progress in Chemistry, 28(8) pp. 1224–1237.

Full text available as:
[img] PDF (Version of Record) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (8MB) | Preview
DOI (Digital Object Identifier) Link:
Google Scholar: Look up in Google Scholar


This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized. As the chemical structure of 4-thiothymidine is very similar to that of its parent thymidine, thus 4-thiothymidine can be readily incorporated into cellular DNA, and with the help of thymidine kinase, much more preferably into cancerous DNA. Unlike thymidine, 4-thiothymdine can absorb strongly in UVA (longer wavelengths of UV) light. Thus UVA-assisted 4-thiothymidine offers an effective cancer treatment. Some underlying mechanisms of action by 4-thiothymidine/UVA and compares this cancer approach with the commonly used photodynamic therapy are discussed. The various interactions between 4-thiothymidine with human serum albumin are introduced. Finally, a short conclusion on the past efforts and a brief prospect for future work in this exciting research field are given.

Item Type: Journal Item
Copyright Holders: 2016 Editorial Board of Progress in Chemistry
ISSN: 1005-281X
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetResearch and Start Fund of the Ministry of Education
Keywords: 4-thiothymidine; photochemical reaction; cell apoptosis; anti-cancer drugs
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 47188
Depositing User: Yao Xu
Date Deposited: 05 Sep 2016 15:32
Last Modified: 03 May 2019 13:18
Share this page:


Altmetrics from Altmetric

Citations from Dimensions

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU