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UVA Assisted 4-Thiothymidine for Cancer Treatment

Ge, Jiang; Feng, Luo; Yaozhong, Xu and Xiaohui, Zhang (2016). UVA Assisted 4-Thiothymidine for Cancer Treatment. Progress in Chemistry, 28(8) pp. 1224–1237.

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URL: http://www.progchem.ac.cn/EN/10.7536/PC151137
DOI (Digital Object Identifier) Link: https://doi.org/10.7536/PC151137
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Abstract

This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized. As the chemical structure of 4-thiothymidine is very similar to that of its parent thymidine, thus 4-thiothymidine can be readily incorporated into cellular DNA, and with the help of thymidine kinase, much more preferably into cancerous DNA. Unlike thymidine, 4-thiothymdine can absorb strongly in UVA (longer wavelengths of UV) light. Thus UVA-assisted 4-thiothymidine offers an effective cancer treatment. Some underlying mechanisms of action by 4-thiothymidine/UVA and compares this cancer approach with the commonly used photodynamic therapy are discussed. The various interactions between 4-thiothymidine with human serum albumin are introduced. Finally, a short conclusion on the past efforts and a brief prospect for future work in this exciting research field are given.

Item Type: Journal Item
Copyright Holders: 2016 Editorial Board of Progress in Chemistry
ISSN: 1005-281X
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetResearch and Start Fund of the Ministry of Education
Keywords: 4-thiothymidine; photochemical reaction; cell apoptosis; anti-cancer drugs
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 47188
Depositing User: Yao Xu
Date Deposited: 05 Sep 2016 15:32
Last Modified: 15 Sep 2017 11:01
URI: http://oro.open.ac.uk/id/eprint/47188
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