Functionalization of biomedical surfaces by peptide aptamers

Rodriguez, Gabriela Melo; Bowen, James and Stamboulis, Artemis (2015). Functionalization of biomedical surfaces by peptide aptamers. In: 27th European Conference on Biomaterials, 30 Aug - 3 Sep 2015, Krakow, Poland.

Abstract

Titanium (Ti) and titanium alloys (Ti6Al4V) are both used in clinical areas for example in orthopaedics, craniofacial, dental and bone replacement due to their exceptional mechanical properties tensile strength, stiffness, fracture toughness and corrosion resistance. The titanium oxide layer plays an important role on the surface of Ti allowing deposition of biomaterials, cells, proteins and peptides. Some studies suggested that a second bioactive material should be deposited, sprayed or attracted to the surface of Ti in order to increase its bioactivity. A well-known material for its high bioactivity is hydroxyapatite (HA)4 and is widely used as coating on implant surfaces. The aim of this project is to increase the interaction of nano hydroxyapatite and titanium oxide using an organic interphase of peptides known as aptamers.

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