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Targeting prostate cancer stem cells.

Crea, Francesco; Mathews, Lesley A.; Farrar, William L. and Hurt, Elaine M. (2009). Targeting prostate cancer stem cells. Anti-cancer agents in medicinal chemistry, 9(10) pp. 1105–1113.

DOI (Digital Object Identifier) Link: https://doi.org/10.2174/187152009789735053
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Abstract

Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

Item Type: Journal Item
Copyright Holders: 2009, Eureka Science Ltd.
ISSN: 1875-5992
Keywords: prostate; cancer stem cells; tumor-initiating cells; molecular therapies; transforming growth factor beta; hedgehog; notch; betacatenin
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 45840
Depositing User: Francesco Crea
Date Deposited: 18 Apr 2016 08:47
Last Modified: 07 Dec 2018 10:39
URI: http://oro.open.ac.uk/id/eprint/45840
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