Targeting prostate cancer stem cells.

Crea, Francesco; Mathews, Lesley A.; Farrar, William L. and Hurt, Elaine M. (2009). Targeting prostate cancer stem cells. Anti-cancer agents in medicinal chemistry, 9(10) pp. 1105–1113.

DOI: https://doi.org/10.2174/187152009789735053

Abstract

Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

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About

• Item ORO ID
• 45840
• Item Type
• Journal Item
• ISSN
• 1875-5992
• Keywords
• prostate; cancer stem cells; tumor-initiating cells; molecular therapies; transforming growth factor beta; hedgehog; notch; betacatenin
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Research Group
• Cancer Research Group
• Copyright Holders
• © 2009, Eureka Science Ltd.
• Depositing User
• Francesco Crea