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Epigenetics and chemoresistance in colorectal cancer: an opportunity for treatment tailoring and novel therapeutic strategies

Crea, Francesco; Nobili, Stefania; Paolicchi, Elisa; Perrone, Gabriele; Napoli, Cristina; Landini, Ida; Danesi, Romano and Mini, Enrico (2011). Epigenetics and chemoresistance in colorectal cancer: an opportunity for treatment tailoring and novel therapeutic strategies. Drug Resistance Updates, 14(6) pp. 280–296.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.drup.2011.08.001
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Abstract

Colorectal cancer is the second leading cause of cancer-related deaths in the world. Despite many therapeutic opportunities, prognosis remains dismal for patients with metastatic disease, and a significant portion of early-stage patients develop recurrence after chemotherapy. Epigenetic gene regulation is a major mechanism of cancer initiation and progression, through the inactivation of several tumor suppressor genes. Emerging evidence indicates that epigenetics may also play a key role in the development of chemoresistance. In the present review, we summarize epigenetic mechanisms triggering resistance to three commonly used agents in colorectal cancer: 5-fluorouracil, irinotecan and oxaliplatin. Those epigenetic biomarkers may help stratify colorectal cancer patients and develop a tailored therapeutic approach. In addition, epigenetic modifications are reversible through specific drugs: histone-deacetylase and DNA-methyl-transferase inhibitors. Preclinical studies suggest that these drugs may reverse chemoresistance in colorectal tumors. In conclusion, an epigenetic approach to colorectal cancer chemoresistance may pave the way to personalized treatment and to innovative therapeutic strategies.

Item Type: Journal Item
Copyright Holders: 2011 Elsevier Ltd.
ISSN: 1532-2084
Keywords: colorectal cancer; epigenetics; chemoresistance; 5-fluorouracil; irinotecan; oxaliplatin; histone deacetylase inhibitors; DNA-methyl-transferase inhibitors
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 45826
Depositing User: Francesco Crea
Date Deposited: 16 May 2016 09:42
Last Modified: 07 Dec 2018 10:39
URI: http://oro.open.ac.uk/id/eprint/45826
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