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Polycomb genes and cancer: time for clinical application?

Crea, Francesco; Paolicchi, Elisa; Marquez, Victor E. and Danesi, Romano (2012). Polycomb genes and cancer: time for clinical application? Critical Reviews in Oncology/Hematology, 83(2) pp. 184–193.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.critrevonc.2011.10.007
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Abstract

Polycomb group genes (PcGs) are epigenetic effectors, essential for stem cell self-renewal and pluripotency. Two main Polycomb repressive complexes (PRC1, PRC2) mediate gene silencing through histone post-translational modifications.

PcGs have been the focus of investigation in cancer research. Many cancer types show an over-expression of PcGs, predicting poor prognosis, metastasis and chemoresistance. Genetic polymorphisms of EZH2 (a PRC2 component) are significantly associated to lung cancer risk. Recently, 3-Deazaneplanocin A (DZNeP) was identified as an efficient inhibitor of PRC2 activity. DZNeP impairs cancer stem cell self-renewal and tumorigenicity.

Despite the well-established role of PcGs in cancer stem cell biology, few studies dissected the clinical significance of these genes. In this paper, we explore PcGs as predictive and prognostic factors in oncology, with particular emphasis on what they can add to current biomarkers. We also propose a model for the rational development of DZNeP-based anticancer regimens and suggest the therapeutic applications of this drug.

Item Type: Journal Item
Copyright Holders: 2011 Elsevier Ireland Ltd
ISSN: 1879-0461
Keywords: polycomb; cancer stem cell; EZH2; BMI1; DZNeP
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 45824
Depositing User: Francesco Crea
Date Deposited: 16 May 2016 09:09
Last Modified: 07 Dec 2018 10:39
URI: http://oro.open.ac.uk/id/eprint/45824
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