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Genome-epigenome interactions: the Polycomb paradox.

Crea, Francesco and Fornaro, Lorenzo (2014). Genome-epigenome interactions: the Polycomb paradox. Epigenomics, 6(1) pp. 5–7.

DOI (Digital Object Identifier) Link: https://doi.org/10.2217/epi.13.86
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Abstract

The last two decades of molecular biology research have revealed that cancer is not simply a genetic disease. Epigenetic alterations, ranging from DNA methylation to histone post-translational modifications, deeply interact with gene mutations, amplifications and deletions. It has been long debated whether epigenetic deregulations precede the appearance of somatic mutations, or if they are simply an "epi-phenomenon" of genetic instability.

Item Type: Journal Item
Copyright Holders: 2014 Future Medicine Ltd
ISSN: 1750-192X
Keywords: copy number alterations; Polycomb; single nucleotide polymorphisms
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 45795
Depositing User: Francesco Crea
Date Deposited: 13 May 2016 10:00
Last Modified: 07 Dec 2018 10:39
URI: http://oro.open.ac.uk/id/eprint/45795
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