Embryonic stem cell pathways and chemotherapy response: an unexplored route.

Duhagon, M. A.; Crea, F.; Danesi, R. and Farrar, W. L. (2013). Embryonic stem cell pathways and chemotherapy response: an unexplored route. Annals of Oncology, 24(2) pp. 558–559.

DOI: https://doi.org/10.1093/annonc/mds610

Abstract

Cancer stem cells (CSCs) are a subpopulation of cancer cells with long-lasting tumorigenic potential. CSCs share with embryonic stem cells (ESCs) an unlimited self-renewal potential and a notable phenotypic plasticity which are sustained by common gene expression programs. CSCs have been associated with drug resistance and relapse in most cancer types. Although CSC-specific pathways were shown to mediate chemoresistance in several preclinical studies, methodological and conceptual complexity has obstructed the examination of this hypothesis in the clinical setting.

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