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Embryonic stem cell pathways and chemotherapy response: an unexplored route.

Duhagon, M. A.; Crea, F.; Danesi, R. and Farrar, W. L. (2013). Embryonic stem cell pathways and chemotherapy response: an unexplored route. Annals of Oncology, 24(2) pp. 558–559.

DOI (Digital Object Identifier) Link: https://doi.org/10.1093/annonc/mds610
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Abstract

Cancer stem cells (CSCs) are a subpopulation of cancer cells with long-lasting tumorigenic potential. CSCs share with embryonic stem cells (ESCs) an unlimited self-renewal potential and a notable phenotypic plasticity which are sustained by common gene expression programs. CSCs have been associated with drug resistance and relapse in most cancer types. Although CSC-specific pathways were shown to mediate chemoresistance in several preclinical studies, methodological and conceptual complexity has obstructed the examination of this hypothesis in the clinical setting.

Item Type: Journal Item
Copyright Holders: 2013, Oxford University Press
ISSN: 1569-8041
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 45793
Depositing User: Francesco Crea
Date Deposited: 13 May 2016 09:20
Last Modified: 07 Dec 2018 10:39
URI: http://oro.open.ac.uk/id/eprint/45793
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