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The epigenetic/noncoding origin of tumor dormancy

Crea, Francesco; Nur Saidy, Nur Ridzwan; Collins, Colin C. and Wang, Yuzhuo (2015). The epigenetic/noncoding origin of tumor dormancy. Trends in molecular medicine, 21(4) pp. 206–11.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.molmed.2015.02.005
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Abstract

Cancer stem cells (CSCs) have been implicated as the seeds of treatment resistance and metastasis, which are the most deadly features of a neoplasm. However, an unequivocal definition of the CSC phenotype is still missing. A common feature of normal and aberrant stem cells is their ability to enter a prolonged dormant state. Cancer dormancy is a key mechanism for treatment resistance and metastasis. Here we propose a unified definition of dormancy-competent CSCs (DCCs) as the neoplastic subpopulation that can plastically alternate periods of dormancy and rapid growth. Irreversible DNA mutations can hardly account for this versatile behavior, and based on emerging evidence we propose that cancer dormancy is a nongenetic disease driven by the flexible nature of the epigenetic/noncoding interactome.

Item Type: Journal Item
Copyright Holders: 2016 Elsevier
ISSN: 1471-499X
Project Funding Details:
Funded Project NameProject IDFunding Body
Not Set5629Michael Smith Foundation for Health Research
Not SetNot SetProstate Cancer Foundation BC
Keywords: dormancy; dormancy-competent cancer stem cells; epigenetic/noncoding interactome; metastasis; therapy resistance
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 45783
Depositing User: Francesco Crea
Date Deposited: 24 Mar 2016 11:13
Last Modified: 07 Dec 2018 10:39
URI: http://oro.open.ac.uk/id/eprint/45783
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