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Techniques and issues in breath and clinical sample headspace analysis for disease diagnosis

Turner, Claire (2016). Techniques and issues in breath and clinical sample headspace analysis for disease diagnosis. Bioanalysis, 8(7) pp. 677–690.

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URL: http://www.future-science.com/doi/full/10.4155/bio...
DOI (Digital Object Identifier) Link: https://doi.org/10.4155/bio.16.22
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Abstract

Analysis of volatile organic compounds (VOCs) from breath or clinical samples for disease diagnosis is an attractive proposition because it is noninvasive and rapid. There are numerous studies showing its potential, yet there are barriers to its development. Sampling and sample handling is difficult, and when coupled with a variety of analytical instrumentation, the same samples can give different results. Background air and the environment a person has been exposed to can greatly affect the VOCs emitted by the body; however, this is not an easy problem to solve. This review investigates the use of VOCs in disease diagnosis, the analytical techniques employed and the problems associated with sample handling and standardization. It then suggests the barriers to future development.

Item Type: Journal Item
Copyright Holders: 2016 Future Science
ISSN: 1757-6199
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Innovation, Knowledge & Development research centre (IKD)
Item ID: 45758
Depositing User: Claire Turner
Date Deposited: 22 Mar 2016 15:27
Last Modified: 26 May 2017 12:19
URI: http://oro.open.ac.uk/id/eprint/45758
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