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Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System.

Heath, Christopher J.; Phillips, Benjamin U.; Bussey, Timothy J. and Saksida, Lisa M. (2016). Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System. In: Gerfen, Charles R.; Holmes, Andrew; Sibley, David; Skolnick, Phil and Wray, Susan eds. Current Protocols in Neuroscience, Volume 74. Chichester: John Wiley & Sons, 8.34.1-8.34.20.

DOI (Digital Object Identifier) Link: https://doi.org/10.1002/0471142301.ns0834s74
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Abstract

This unit is designed to facilitate implementation of the fixed and progressive ratio paradigms and the effort-related choice task in the rodent touchscreen apparatus to permit direct measurement of motivation and reward-related decision making in this equipment. These protocols have been optimized for use in the mouse and reliably yield stable performance levels that can be enhanced or suppressed by systemic pharmacological manipulation. Instructions are also provided for the adjustment of task parameters to permit use in mouse models of neurodegenerative disease. These tasks expand the utility of the rodent touchscreen apparatus beyond the currently available battery of cognitive assessment paradigms.

Item Type: Book Section
Copyright Holders: 2016 by John Wiley & Sons, Inc.
ISBN: 0-471-14230-1, 978-0-471-14230-0
ISSN: 1934-8576
Extra Information: Online ISSN: 1934-8576
Keywords: touchscreen; motivation; effort‐related choice; mouse
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 45753
Depositing User: Christopher Heath
Date Deposited: 21 Mar 2016 09:34
Last Modified: 07 Dec 2018 10:39
URI: http://oro.open.ac.uk/id/eprint/45753
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