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Simulated annealing approach to vascular structure with application to the coronary arteries

Keelan, Jonathan; Chung, Emma M. L. and Hague, James P. (2016). Simulated annealing approach to vascular structure with application to the coronary arteries. Royal Society Open Science, 3(2) pp. 150431–150445.

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Do the complex processes of angiogenesis during organism development ultimately lead to a near optimal coronary vasculature in the organs of adult mammals? We examine this hypothesis using a powerful and universal method, built on physical and physiological principles, for the determination of globally energetically optimal arterial trees. The method is based on simulated annealing, and can be used to examine arteries in hollow organs with arbitrary tissue geometries. We demonstrate that the approach can generate in silico vasculatures which closely match porcine anatomical data for the coronary arteries on all length scales, and that the optimized arterial trees improve systematically as computational time increases. The method presented here is general, and could in principle be used to examine the arteries of other organs. Potential applications include improvement of medical imaging analysis and the design of vascular trees for artificial organs.

Item Type: Journal Item
Copyright Holders: 2016 The Authors
ISSN: 2054-5703
Project Funding Details:
Funded Project NameProject IDFunding Body
Doctoral training accountEP/P505046/1EPSRC
Intermediate basic science research fellowshipFS/10/46/28350BHF
Keywords: vascular modelling; optimization; cardiovascular systems; simulated annealing
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Centre for Electronic Imaging (CEI)
Item ID: 45544
Depositing User: James Hague
Date Deposited: 07 Mar 2016 14:21
Last Modified: 18 Nov 2019 01:51
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