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Electrospray synthesis and properties of hierarchically structured PLGA TI PS microspheres for use as controlled release technologies

Malik, Salman A.; Ng, Wing H.; Bowen, James; Tang, Justin; Gomez, Alessandro; Kenyon, Anthony J. and Day, Richard M. (2016). Electrospray synthesis and properties of hierarchically structured PLGA TI PS microspheres for use as controlled release technologies. Journal of Colloid and Interface Science, 467 pp. 220–229.

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Microsphere-based controlled release technologies have been utilized for the long-term delivery of proteins, peptides and antibiotics, although their synthesis poses substantial challenges owing to formulation complexities, lack of scalability, and cost. To address these shortcomings, we used the electrospray process as a reproducible, synthesis technique to manufacture highly porous (>94%) microspheres while maintaining control over particle structure and size. Here we report a successful formulation recipe used to generate spherical poly(lactic-co-glycolic) acid (PLGA) microspheres using the electrospray (ES) coupled with a novel thermally induced phase separation (TIPS) process with a tailored Liquid Nitrogen (LN2) collection scheme. We show how size, shape and porosity of resulting microspheres can be controlled by judiciously varying electrospray processing parameters and we demonstrate examples in which the particle size (and porosity) affect release kinetics. The effect of electrospray treatment on the particles and their physicochemical properties are characterized by scanning electron microscopy, confocal Raman microscopy, thermogravimetric analysis and mercury intrusion porosimetry. The microspheres manufactured here have successfully demonstrated long-term delivery (i.e. 1 week) of an active agent, enabling sustained release of a dye with minimal physical degradation and have verified the potential of scalable electrospray technologies for an innovative TIPS-based microsphere production protocol.

Item Type: Journal Item
Copyright Holders: 2016 The Authors
ISSN: 0021-9797
Project Funding Details:
Funded Project NameProject IDFunding Body
Doctoral Training AwardNot SetEPSRC
EPSRC Global Engagement AwardEP/K004506/1The UCL Institute of Biomedical Engineering (IBME) Yale-UCL
Not SetNot SetDepartment of Biomedical Engineering at Yale University
Keywords: Electrosprays; Poly(lactic-co-glycolic acid) (PLGA); Microspheres; Thermally induced phase separation (TIPS)
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Related URLs:
Item ID: 45245
Depositing User: James Bowen
Date Deposited: 17 Feb 2016 16:49
Last Modified: 02 May 2019 10:34
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