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Mackenzie Ross, Sarah; McManus, Chris; Harrison, Virginia and Mason, Oliver
(2015).
DOI: https://doi.org/10.1016/j.envint.2015.10.009
Abstract
We undertook a systematic review (incorporating meta-analysis) of the literature concerning the neurotoxicity of cumulative low level occupational exposure to organophosphate pesticides, which was published online by the journal Critical Reviews in Toxicology in 2012. As far as we are aware, we were the first research team to attempt quantitative evaluation of study findings on this topic, using meta-analysis. We wish to encourage others to apply systematic review techniques in chemical risk assessment to reduce bias, increase transparency and better inform public policy. We thought it would be useful to share our experience of undertaking a systematic review in the hope of dispelling misconceptions about the complexity, time and resource issues involved along with the view that meta-analysis is meaningless when studies are not homogeneous. In this commentary paper we reflect on aspects of the process which were relatively straightforward; aspects which were more challenging; the advantages of using systematic review techniques; and the advantages and limitations of using statistical techniques such as meta-analysis in this context.
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About
- Item ORO ID
- 45183
- Item Type
- Journal Item
- ISSN
- 1873-6750
- Keywords
- systematic review; meta-analysis; organophosphates; low-level exposure; neurobehavioural function
- Academic Unit or School
-
Faculty of Arts and Social Sciences (FASS) > Psychology and Counselling > Psychology
Faculty of Arts and Social Sciences (FASS) > Psychology and Counselling
Faculty of Arts and Social Sciences (FASS) - Research Group
- Harm and Evidence Research Collaborative (HERC)
- Copyright Holders
- © 2015 Elsevier Ltd
- Depositing User
- Virginia Harrison