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Neural hypernetwork approach for pulmonary embolism diagnosis

Rucco, Matteo; Sousa-Rodriges, David; Merelli, Emanuela; Johnson, Jeffrey H.; Falsetti, Lorenzo; Nitti, Cinzia and Salvi, Aldo (2015). Neural hypernetwork approach for pulmonary embolism diagnosis. BMC Research Notes, 8(617)

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Hypernetworks are based on topological simplicial complexes and generalize the concept of two-body relation to many-body relation. Furthermore, Hypernetworks provide a significant generalization of network theory, enabling the integration of relational structure, logic and analytic dynamics. A pulmonary embolism is a blockage of the main artery of the lung or one of its branches, frequently fatal.

Our study uses data on 28 diagnostic features of 1427 people considered to be at risk of pulmonary embolism enrolled in the Department of Internal and Subintensive Medicine of an Italian National Hospital “Ospedali Riuniti di Ancona”. Patients arrived in the department after a first screening executed by the emergency room. The resulting neural hypernetwork correctly recognized 94 % of those developing pulmonary embolism. This is better than previous results obtained with other methods (statistical selection of features, partial least squares regression, topological data analysis in a metric space).

In this work we successfully derived a new integrative approach for the analysis of partial and incomplete datasets that is based on Q-analysis with machine learning. The new approach, called Neural Hypernetwork, has been applied to a case study of pulmonary embolism diagnosis. The novelty of this method is that it does not use clinical parameters extracted by imaging analysis.

Item Type: Journal Item
Copyright Holders: 2015 Rucco et al
ISSN: 1756-0500
Project Funding Details:
Funded Project NameProject IDFunding Body
Topology Driven Methods in Complex SystemsFP7-ICT-318121European Commission
Keywords: TOPDRIM; Hypernetworks; Q-analysis; Pulmonary embolism; Topology of data; Machine learning; artificial neural network
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Design and Innovation
Item ID: 45041
Depositing User: Jeffrey Johnson
Date Deposited: 24 Dec 2015 11:24
Last Modified: 10 Dec 2018 00:44
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