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Auditory responses in a rodent model of Attention Deficit Hyperactivity Disorder

Brace, Louise R.; Kraev, Igor; Rostron, Claire L.; Stewart, Michael G.; Overton, Paul G. and Dommett, Eleanor J. (2015). Auditory responses in a rodent model of Attention Deficit Hyperactivity Disorder. Brain Research, 1629 pp. 10–25.

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A central component of Attention Deficit Hyperactivity Disorder (ADHD) is increased distractibility in response to visual and auditory stimuli, which is linked to the superior colliculus (SC). Furthermore, there is now mounting evidence of altered collicular functioning in ADHD and it is proposed that a hyper-responsive SC could mediate symptoms of ADHD, including distractibility. In the present study we conducted a systematic characterisation of the intermediate and deep layers of the SC in the most commonly used and well-validated model of ADHD, the spontaneously hypertensive rat (SHR), building on prior work showing increased distractible behaviour in this strain using visual distractors. We examined collicular-dependent orienting behaviour, local field potential (LFP) and multiunit activity (MUA) in response to auditory stimuli in the anaesthetised rat, and morphological measures, in the SHR in comparison to the Wistar Kyoto (WKY) and Wistar (WIS). We found no evidence of increased distractibility in the behavioural data but suggest that this may arise due to cochlear hearing loss in the SHR. Furthermore, the electrophysiology data indicate that the SC in the SHR may still be hyper-responsive, normalising the amplitude of auditory responses that would otherwise be reduced due to the hearing impairment. The morphological measures of collicular volume, cell density and ratios did not indicate this potential hyper-responsiveness had a basis at the structural level examined. These findings have implications for future use of the SHR in auditory processing studies and may represent a limitation to the validity of this animal model.

Item Type: Journal Item
Copyright Holders: 2015 Elsevier B.V.
ISSN: 1872-6240
Project Funding Details:
Funded Project NameProject IDFunding Body
Ph.D. studentshipNot SetBRN (Biomedical Research Network) - The Open University
Keywords: spontaneously hypertensive rat; superior colliculus; orienting; distractibility; hearing loss; validity
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Centre for Research in Computing (CRC)
Item ID: 44637
Depositing User: Michael Stewart
Date Deposited: 16 Oct 2015 15:07
Last Modified: 07 Dec 2018 10:35
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