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The importance of Wnt signalling for neurodegeneration in Parkinson's disease

Berwick, Daniel C. and Harvey, Kirsten (2012). The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochemical Society Transactions, 40(5) pp. 1123–1128.

DOI (Digital Object Identifier) Link: https://doi.org/10.1042/BST20120122
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Abstract

PD (Parkinson's disease) is a devastating progressive motor disorder with no available cure. Over the last two decades, an increasing number of genetic defects have been found that cause familial and idiopathic forms of PD. In parallel, the importance of Wnt signalling pathways for the healthy functioning of the adult brain and the dysregulation of these pathways in neurodegenerative disease has become apparent. Cell biological functions disrupted in PD are partially controlled by Wnt signalling pathways and proteins encoded by PARK genes have been shown to modify Wnt signalling. This suggests the prospect of targeting Wnt signalling pathways to modify PD progression.

Item Type: Journal Item
ISSN: 1470-8752
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 44276
Depositing User: Daniel Berwick
Date Deposited: 06 Oct 2015 11:22
Last Modified: 20 May 2019 10:10
URI: http://oro.open.ac.uk/id/eprint/44276
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