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Interactions between epicardial adipose tissue and cardiomyocytes: results from a 3D co-culture system

Rietdorf, Katja and MacQueen, Hilary (2015). Interactions between epicardial adipose tissue and cardiomyocytes: results from a 3D co-culture system. In: Pharmacology 2015 (British Pharmacological Society), 15-17 December 2015, London.

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Abstract

We report a study of the interactions between epicardial adipose tissue, which is tightly apposed to the heart in vivo, and cardiomyocytes, using rat cells in a novel 3D co-culture system. Our findings are that in addition to being a local source of energy-rich fatty acids which support cardiac function, adipocytes are a source of paracrine factors that modulate the amplitude and rate of contraction. This is achieved by changes in a number of cardiomyocyte signalling pathways.

Item Type: Conference or Workshop Item
Copyright Holders: 2015 The Authors
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
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Item ID: 44165
Depositing User: Hilary MacQueen
Date Deposited: 30 Sep 2015 09:30
Last Modified: 29 Nov 2016 16:11
URI: http://oro.open.ac.uk/id/eprint/44165
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