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Rho deep in thought.

Mcmullan, Rachel and Nurrish, Stephen J. (2007). Rho deep in thought. Genes & Development, 21(21) pp. 2677–82.

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Neuronal communication underlies all aspects of brain function, including learning, memory, and consciousness. How neurons communicate is controlled by both the formation of neuronal connections during neural development and the regulation of neuronal activity in the adult brain. Rho GTPases have a well-known role in neuronal development, and recent studies published in Genes & Development (Steven et al. 2005; McMullan et al. 2006) have demonstrated that they also regulate neuronal activity in the adult brain—at least in Caenorhabditis elegans. Rho in C. elegans acts as part of a network of Gαq pathways that increase neuronal activity by regulating both production and destruction of the second messenger diacylglycerol (DAG), which is a regulator of synaptic vesicle release. In this issue of Genes & Development, Williams et al. (2007) demonstrate that Gαq acts via the UNC-73RhoGEF to increase Rho activity in neurons, and thus increase levels of DAG. The targets of DAG are known and, in one case, a pathway stretching from binding of ligand on the cell surface to changes in synaptic vesicle priming has been mapped out.

Item Type: Journal Item
Copyright Holders: 2007 Cold Spring Harbor Laboratory
ISSN: 1549-5477
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 44162
Depositing User: Rachel Mcmullan
Date Deposited: 25 Aug 2015 09:29
Last Modified: 11 Dec 2018 20:16
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