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The RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans.

Mcmullan, Rachel and Nurrish, Stephen J. (2011). The RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans. PLoS ONE, 6(2), article no. e17265.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1371/journal.pone.0017265
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Abstract

The Rho family of small GTPases are essential during early embryonic development making it difficult to study their functions in adult animals. Using inducible transgenes expressing either a constitutively active version of the single C. elegans Rho ortholog, RHO-1, or an inhibitor of endogenous Rho (C3 transferase), we demonstrate multiple defects caused by altering Rho signaling in adult C. elegans. Changes in RHO-1 signaling in cholinergic neurons affected locomotion, pharyngeal pumping and fecundity. Changes in RHO-1 signaling outside the cholinergic neurons resulted in defective defecation, ovulation, and changes in C. elegans body morphology. Finally both increased and decreased RHO-1 signaling in adults resulted in death within hours. The multiple post-developmental roles for Rho in C. elegans demonstrate that RhoA signaling pathways continue to be used post-developmentally and the resulting phenotypes provide an opportunity to further study post-developmental Rho signaling pathways using genetic screens.

Item Type: Journal Item
Copyright Holders: 2011 McMullan, Nurrish
ISSN: 1932-6203
Extra Information: 13 pp.
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 44158
Depositing User: Rachel Mcmullan
Date Deposited: 25 Aug 2015 08:42
Last Modified: 07 Dec 2018 16:04
URI: http://oro.open.ac.uk/id/eprint/44158
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