Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing.

Heath, Christopher J. and Picciotto, Marina R. (2009). Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology, 56(Sup 1) pp. 254–262.

DOI (Digital Object Identifier) Link:	https://doi.org/10.1016/j.neuropharm.2008.07.020
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Abstract

Despite a great deal of progress, more than 10% of pregnant women in the USA smoke. Epidemiological studies have demonstrated correlations between developmental tobacco smoke exposure and sensory processing deficits, as well as a number of neuropsychiatric conditions, including attention deficit hyperactivity disorder. Significantly, data from animal models of developmental nicotine exposure have suggested that the nicotine in tobacco contributes significantly to the effects of developmental smoke exposure. Consequently, we hypothesize that nicotinic acetylcholine receptors (nAChRs) are important for setting and refining the strength of corticothalamic-thalamocortical loops during critical periods of development and that disruption of this process by developmental nicotine exposure can result in long-lasting dysregulation of sensory processing. The ability of nAChR activation to modulate synaptic plasticity is likely to underlie the effects of both endogenous cholinergic signaling and pharmacologically administered nicotine to alter cellular, physiological and behavioral processes during critical periods of development.

Item Type:	Journal Item
Copyright Holders:	2008 Elsevier Ltd.
ISSN:	1873-7064
Extra Information:	Frontiers in Addiction Research: Celebrating the 35th Anniversary of the National Institute on Drug Abuse
Keywords:	nicotine; fetal development; attention deficit hyperactivity disorder; sensory processing; thalamus; cortex
Academic Unit/School:	Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID:	44151
Depositing User:	Christopher Heath
Date Deposited:	23 Sep 2015 09:34
Last Modified:	07 Dec 2018 10:34
URI:	http://oro.open.ac.uk/id/eprint/44151
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