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Heath, Christopher J. and Picciotto, Marina R.
(2009).
DOI: https://doi.org/10.1016/j.neuropharm.2008.07.020
Abstract
Despite a great deal of progress, more than 10% of pregnant women in the USA smoke. Epidemiological studies have demonstrated correlations between developmental tobacco smoke exposure and sensory processing deficits, as well as a number of neuropsychiatric conditions, including attention deficit hyperactivity disorder. Significantly, data from animal models of developmental nicotine exposure have suggested that the nicotine in tobacco contributes significantly to the effects of developmental smoke exposure. Consequently, we hypothesize that nicotinic acetylcholine receptors (nAChRs) are important for setting and refining the strength of corticothalamic-thalamocortical loops during critical periods of development and that disruption of this process by developmental nicotine exposure can result in long-lasting dysregulation of sensory processing. The ability of nAChR activation to modulate synaptic plasticity is likely to underlie the effects of both endogenous cholinergic signaling and pharmacologically administered nicotine to alter cellular, physiological and behavioral processes during critical periods of development.
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About
- Item ORO ID
- 44151
- Item Type
- Journal Item
- ISSN
- 1873-7064
- Extra Information
- Frontiers in Addiction Research: Celebrating the 35th Anniversary of the National Institute on Drug Abuse
- Keywords
- nicotine; fetal development; attention deficit hyperactivity disorder; sensory processing; thalamus; cortex
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Research Group
- Neuroscience Research Group
- Copyright Holders
- © 2008 Elsevier Ltd.
- Depositing User
- Christopher Heath