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Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents.

Jacobsen, Leslie K.; Picciotto, Marina R.; Heath, Christopher J.; Mencl, W. Einar and Gelernter, Joel (2009). Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents. Biological Psychiatry, 65(8) pp. 671–679.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.biopsych.2008.10.024
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Abstract

Background
Exposure to nicotine in tobacco smoke during development has been linked to subsequent deficits in attention and memory. The present study tested for evidence that genetic variation may contribute to individual differences in vulnerability to the effects of developmental exposure to tobacco smoke on memory and medial temporal lobe function in adolescents.

Methods
Verbal and visuospatial memory were assessed and functional magnetic resonance imaging (fMRI) data were acquired in 101 adolescents systematically characterized for prenatal and adolescent exposure to tobacco smoke, while they performed an encoding and recognition memory task. The impact of allelic variation at loci within CLSTN2 (encoding synaptic protein calsyntenin 2) and KIBRA, shown previously to modulate early and delayed recall of words, on the dependent measures was examined.

Results
KIBRA genotype did not exert significant main or interacting effects with prenatal or adolescent exposure to tobacco smoke on verbal or visuospatial memory. Previous observations of a beneficial effect of the CLSTN2 C allele on verbal recall were replicated. Adolescent exposure to tobacco smoke reversed this beneficial effect and was associated with increased activation of parahippocampal gyrus during early and delayed recognition in CLTSN2 C allele carriers. While the CLSTN2 C allele conferred enhanced functional connectivity between brain regions subserving accurate verbal recognition, adolescent exposure to tobacco smoke reversed this effect.

Conclusions
These findings extend previous work demonstrating that calsyntenins play an essential role in learning and indicate that this role is modulated both by CLSTN2 genotype and, during adolescent development, by exposure to tobacco smoke.

Item Type: Journal Item
Copyright Holders: 2009 Society of Biological Psychiatry
ISSN: 1873-2402
Extra Information: Interplay of Glutamate and Dopamine in Addiction
Keywords: adolescent; calsyntenin 2; nicotine; parahippocampal gyrus; prenatal; verbal memory
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 44150
Depositing User: Christopher Heath
Date Deposited: 23 Sep 2015 09:44
Last Modified: 07 Dec 2018 10:34
URI: http://oro.open.ac.uk/id/eprint/44150
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