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The touchscreen operant platform for testing learning and memory in rats and mice.

Horner, Alexa E.; Heath, Christopher J.; Hvoslef-Eide, Martha; Kent, Brianne A.; Kim, Chi Hun; Nilsson, Simon R. O.; Alsiö, Johan; Oomen, Charlotte A.; Holmes, Andrew; Saksida, Lisa M. and Bussey, Timothy J. (2013). The touchscreen operant platform for testing learning and memory in rats and mice. Nature Protocols, 8(10) pp. 1961–84.

DOI (Digital Object Identifier) Link: https://doi.org/10.1038/nprot.2013.122
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Abstract

An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive tests can be run in a manner very similar to touchscreen methods currently used to test human subjects. This methodology is low stress (using appetitive rather than aversive reinforcement), has high translational potential and lends itself to a high degree of standardization and throughput. Applications include the study of cognition in rodent models of psychiatric and neurodegenerative diseases (e.g., Alzheimer's disease, schizophrenia, Huntington's disease, frontotemporal dementia), as well as the characterization of the role of select brain regions, neurotransmitter systems and genes in rodents. This protocol describes how to perform four touchscreen assays of learning and memory: visual discrimination, object-location paired-associates learning, visuomotor conditional learning and autoshaping. It is accompanied by two further protocols (also published in this issue) that use the touchscreen platform to assess executive function, working memory and pattern separation.

Item Type: Journal Item
Copyright Holders: 2013 Rights Managed by Nature Publishing Group
ISSN: 1750-2799
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 44145
Depositing User: Christopher Heath
Date Deposited: 23 Sep 2015 09:56
Last Modified: 07 Dec 2018 10:34
URI: http://oro.open.ac.uk/id/eprint/44145
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