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The role of the dorsal hippocampus in two versions of the touchscreen automated paired associates learning (PAL) task for mice.

Kim, Chi Hun; Heath, Christopher J.; Kent, Brianne A.; Bussey, Timothy J. and Saksida, Lisa M. (2015). The role of the dorsal hippocampus in two versions of the touchscreen automated paired associates learning (PAL) task for mice. Psychopharmacology, 232(21) pp. 3899–3910.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1007/s00213-015-3949-3
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Abstract

Rationale
The CANTAB object-location paired-associate learning (PAL) test can detect cognitive deficits in schizophrenia and Alzheimer’s disease. A rodent version of touch screen PAL (dPAL) has been developed, but the underlying neural mechanisms are not fully understood. Although there is evidence that inactivation of the hippocampus following training leads to impairments in rats, this has not been tested in mice. Furthermore, it is not known whether acquisition, as opposed to performance, of the rodent version depends on the hippocampus. This is critical as many mouse models may have hippocampal dysfunction prior to the onset of task training.

Objectives
The objectives of this study are to examine the effects of dorsal hippocampal (dHp) dysfunction on both performance and acquisition of mouse dPAL and to determine if hippocampal task sensitivity could be increased using a newly developed context-disambiguated PAL (cdPAL) paradigm.

Methods
In experiment 1, C57Bl/6 mice received post-acquisition dHp infusions of the GABA agonist muscimol. In experiment 2, C57Bl/6 mice received excitotoxic dHp lesions prior to dPAL/cdPAL acquisition.

Results
Post-acquisition muscimol dose-dependently impaired dPAL and cdPAL performance. Pre-acquisition dHp lesions had only mild effects on both PAL tasks. Behavioural challenges including addition of objects and degradation of the visual stimuli with noise did not reveal any further impairments.

Conclusions
dPAL and cdPAL performance is hippocampus-dependent in the mouse, but both tasks can be learned in the absence of a functional dHp.

Item Type: Journal Item
Copyright Holders: 2015 The Authors
ISSN: 1432-2072
Extra Information: An erratum to this article can be found at http://​dx.​doi.​org/​10.​1007/​s00213-015-4025-8.
Keywords: mouse; paired-associate learning; hippocampus; touch screen operant chamber
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 44143
Depositing User: Christopher Heath
Date Deposited: 24 Sep 2015 09:34
Last Modified: 08 Dec 2018 02:12
URI: http://oro.open.ac.uk/id/eprint/44143
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