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The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia

Hvoslef-Eide, M.; Mar, A. C.; Nilsson, S. R. O.; Alsiö, J.; Heath, C. J.; Saksida, L. M.; Robbins, T. W. and Bussey, T. J. (2015). The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia. Psychopharmacology

DOI (Digital Object Identifier) Link: https://doi.org/10.1007/s00213-015-4007-x
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Abstract

Rationale.
The NEWMEDS initiative (Novel Methods leading to New Medications in Depression and Schizophrenia, http://​www.​newmeds-europe.​com) is a large industrial-academic collaborative project aimed at developing new methods for drug discovery for schizophrenia. As part of this project, Work package 2 (WP02) has developed and validated a comprehensive battery of novel touchscreen tasks for rats and mice for assessing cognitive domains relevant to schizophrenia.
Objectives.
This article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere.
Methods.
The battery consists of the five-choice serial reaction time task and a novel rodent continuous performance task for measuring attention, a three-stimulus visual reversal and the serial visual reversal task for measuring cognitive flexibility, novel non-matching to sample-based tasks for measuring spatial working memory and paired-associates learning for measuring long-term memory.
Results.
The rodent (i.e. both rats and mice) touchscreen operant chamber and battery has high translational value across species due to its emphasis on construct as well as face validity. In addition, it offers cognitive profiling of models of diseases with cognitive symptoms (not limited to schizophrenia) through a battery approach, whereby multiple cognitive constructs can be measured using the same apparatus, enabling comparisons of performance across tasks.
Conclusion.
This battery of tests constitutes an extensive tool package for both model characterisation and pre-clinical drug discovery.

Item Type: Journal Item
Copyright Holders: 2015 Springer-Verlag Berlin Heidelberg
ISSN: 1432-2072
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetFP7/2007-2013European Union
Keywords: Drug discovery; Neuropsychiatric disease; attention; working memory; long-term memory; executive function; cognitive flexibility; response inhibition; rat; mouse
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 44140
Depositing User: Christopher Heath
Date Deposited: 29 Sep 2015 15:10
Last Modified: 07 Dec 2018 10:34
URI: http://oro.open.ac.uk/id/eprint/44140
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