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Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

McLaurin, JoAnne; Kierstead, Meredith E.; Brown, Mary E.; Hawkes, Cheryl A.; Lambermon, Mark H. L.; Phinney, Amie L.; Darabie, Audrey A.; Cousins, Julian E.; French, Janet E.; Lan, Melissa F.; Chen, Fusheng; Wong, Sydney S.N.; Mount, Howard T. J.; Fraser, Paul E.; Westaway, David and St. George-Hyslop, Peter (2006). Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nature Medicine, 12(7) pp. 801–808.

DOI (Digital Object Identifier) Link: https://doi.org/10.1038/nm1423
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Abstract

When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid β peptide (Aβ) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease–like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Aβ pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease–like phenotype, support the idea that the accumulation of Aβ oligomers has a central role in the pathogenesis of Alzheimer disease.

Item Type: Journal Item
Copyright Holders: 2006, Rights managed by Nature Publishing Group
ISSN: 1546-170X
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
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Item ID: 44106
Depositing User: Cheryl Hawkes
Date Deposited: 07 Sep 2015 08:48
Last Modified: 07 Dec 2018 10:34
URI: http://oro.open.ac.uk/id/eprint/44106
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