The Open UniversitySkip to content
 

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation

Sun, Yedi; Zhang, Guohau; Hawkes, Cheryl A.; Shaw, James E.; McLaurin, JoAnne and Nitz, Mark (2008). Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation. Bioorganic & Medicinal Chemistry, 16(15) pp. 7177–7184.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.bmc.2008.06.045
Google Scholar: Look up in Google Scholar

Abstract

scyllo-Inositol has shown promise as a potential therapeutic for Alzheimer’s disease, by directly interacting with the amyloid β (Aβ) peptide to inhibit Aβ42 fiber formation. To explore the molecular details of the inositol-Aβ42 interaction, a series of scyllo-inositol derivatives have been synthesized which contain deoxy, fluoro, chloro, and methoxy substitutions. The effects of these compounds on the aggregation cascade of Aβ42 have been investigated using electron microscopy (EM). EM analyses revealed that the 1-deoxy-1-fluoro- and 1,4-dimethyl-scyllo-inositols significantly inhibit the formation of Aβ42 fibers. The other derivatives showed some alterations in the morphology of the Aβ42 fibers produced. These findings indicate the importance of all of the hydroxyl groups of </i>scyllo</i>-inositol for complete inhibition of Aβ aggregation.

Item Type: Journal Item
Copyright Holders: 2008 Elsevier Ltd.
ISSN: 1464-3391
Keywords: scyllo-inositol; Alzheimer’s; amyloid; inositol; Aβ peptide; aggregation inhibitors
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Related URLs:
Item ID: 44099
Depositing User: Cheryl Hawkes
Date Deposited: 07 Sep 2015 09:51
Last Modified: 07 Dec 2018 10:34
URI: http://oro.open.ac.uk/id/eprint/44099
Share this page:

Metrics

Altmetrics from Altmetric

Citations from Dimensions

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU