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The cerebrovascular basement membrane: Role in the clearance of β-amyloid and cerebral amyloid angiopathy

Morris, Alan W. J.; Carare, Roxana O.; Schreiber, Stefanie and Hawkes, Cheryl A. (2014). The cerebrovascular basement membrane: Role in the clearance of β-amyloid and cerebral amyloid angiopathy. Frontiers in Aging Neuroscience, 6, article no. 251.

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DOI (Digital Object Identifier) Link: https://doi.org/10.3389/fnagi.2014.00251
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Abstract

Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) peptides in the walls of cerebral blood vessels, is observed in the majority of Alzheimer’s disease (AD) brains and is thought to be due to a failure of the aging brain to clear Aβ. Perivascular drainage of Aβ along cerebrovascular basement membranes (CVBMs) is one of the mechanisms by which Aβ is removed from the brain. CVBMs are specialized sheets of extracellular matrix that provide structural and functional support for cerebral blood vessels. Changes in CVBM composition and structure are observed in the aged and AD brain and may contribute to the development and progression of CAA. This review summarizes the properties of the CVBM, its role in mediating clearance of interstitial fluids and solutes from the brain, and evidence supporting a role for CVBM in the etiology of CAA.

Item Type: Journal Item
Copyright Holders: 2014 Morris, Carare, Schreiber and Hawkes.
ISSN: 1663-4365
Extra Information: 9 pp.

This article is part of the research topic: Clearance pathways for Amyloid-β. Significance for Alzheimer’s disease and its Therapy
Keywords: Alzheimer’s disease; cerebral amyloid angiopathy; perivascular drainage; basement membrane; β-amyloid
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
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Item ID: 44082
Depositing User: Cheryl Hawkes
Date Deposited: 11 Sep 2015 09:50
Last Modified: 09 Dec 2018 06:30
URI: http://oro.open.ac.uk/id/eprint/44082
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