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Electrospun diclofenac sodium loaded Eudragit® L 100-55 nanofibers for colon-targeted drug delivery

Shen, Xiaxia; Yu, Dengguang; Zhu, Limin; Branford-White, Christopher; White, Kenneth and Chatterton, Nicholas P. (2011). Electrospun diclofenac sodium loaded Eudragit® L 100-55 nanofibers for colon-targeted drug delivery. International Journal of Pharmaceutics, 408(1-2) pp. 200–207.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.ijpharm.2011.01.058
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Abstract

Eudragit® L 100-55 nanofibers loaded with diclofenac sodium (DS) were successfully prepared using an electrospinning process, and characterized for structural and pharmacodynamic properties. The influence of solvent and drug content on fiber formation and quality was also investigated. Fiber formation was successful using a solvent mixture 5:1 (v/v) ethanol:DMAc. XRD and DSC analysis of fibers confirm electron microscopic evidence that DS is evenly distributed in the nanofibers in an amorphous state. FTIR analysis indicates hydrogen bonding occurs between the drug and the polymer, which accounts for the molecular integration of the two components. In vitro dissolution tests verified that all the drug-loaded Eudragit® L 100-55 nanofibers had pH-dependent drug release profiles, with limited, less than 3%, release at pH 1.0, but a sustained and complete release at pH 6.8. This profile of properties indicates drug-loaded Eudragit® L 100-55 nanofibers have the potential to be developed as oral colon-targeted drug delivery systems.

Item Type: Journal Item
Copyright Holders: 2011 Elsevier B.V.
ISSN: 1873-3476
Keywords: electrospinning; drug-loaded nanofibers; Eudragit® L 100-55; colon-targeted drug delivery
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 43988
Depositing User: Nicholas Chatterton
Date Deposited: 17 Aug 2015 08:28
Last Modified: 07 Jul 2020 07:46
URI: http://oro.open.ac.uk/id/eprint/43988
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