Self-assembled liposomes from amphiphilic electrospun nanofibers

Yu, Deng-Guang; Branford-White, Christopher; Williams, Gareth R.; Bligh, S. W. Annie; White, Kenneth; Zhu, Li-Min and Chatterton, Nicholas P. (2011). Self-assembled liposomes from amphiphilic electrospun nanofibers. Soft Matter, 7(18) pp. 8239–8247.

DOI: https://doi.org/10.1039/c1sm05961k

Abstract

Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1–33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.

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