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Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems

Wu, Xiao-mei; Branford-White, Christopher J.; Zhu, Li-min; Chatterton, Nicholas P. and Yu, Deng-guang (2010). Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems. Journal of Materials Science: Materials in Medicine, 21(8) pp. 2403–2411.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1007/s10856-010-4100-y
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Abstract

Cellulose acetate (CA) fibers loaded with the ester prodrugs of naproxen, including methyl ester, ethyl ester and isopropyl ester, were prepared through electrospinning using acetone/N,N-dimethylacetamide(DMAc)/ethanol (4:1:1, v/v/v) as solvent. The chemical and morphological characterizations of the medicated fibers were investigated by means of SEM, DSC, XRD and FTIR, as well as the studies of the drug release properties. The results indicated that the morphology and diameter of the fibers were influenced by the concentration of spinning solution, applied voltage, electrospun solvent and the surfactants. The average diameters of the fibers ranged between 100 and 500 nm for three prodrugs. There was good compatibility between CA and three prodrugs in the blended fibers, respectively. In vitro release indicated that constant drug release from the fiber was observed over 6 days. The prodrugs were successfully encapsulated into the fibers, and this system was stable in terms of effectiveness in release.

Item Type: Journal Item
Copyright Holders: 2010 Springer Science+Business Media, LLC
ISSN: 1573-4838
Extra Information: Special Section: Selected papers from the Northern Ireland Biomedical Engineering Society Spring Meeting, 2009
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 43983
Depositing User: Nicholas Chatterton
Date Deposited: 14 Aug 2015 09:32
Last Modified: 11 Jun 2020 16:32
URI: http://oro.open.ac.uk/id/eprint/43983
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