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Mebeverine-loaded electrospun nanofibers: physicochemical characterization and dissolution studies

Illangakoon, Upulitha Eranka; Nazir, Tahir; Williams, Gareth R. and Chatterton, Nicholas P. (2014). Mebeverine-loaded electrospun nanofibers: physicochemical characterization and dissolution studies. Journal of Pharmaceutical Sciences, 103(1) pp. 283–292.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1002/jps.23759
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Abstract

Both fast dissolving and sustained release drug delivery systems (DDSs) comprising mebeverine hydrochloride (MB-HCl) embedded in either povidone (PVP) K60 or Eudragit® L 100-55 nanofibers have been prepared by electrospinning. The fibers are found to have cylindrical morphologies with smooth surfaces, except at high drug loadings that appear to induce surface roughness (PVP) or fragmentation (Eudragit). There is a general increase in fiber diameter with drug loading. Differential scanning calorimetry and X-ray diffraction demonstrate that the drug exists in an amorphous state in the fibers. Infrared spectroscopy data indicate that the drug has good compatibility with the polymer, whereas nuclear magnetic resonance spectroscopy and high-performance liquid chromatography analyses confirmed that the MB-HCl was not degraded during the spinning process. In vitro dissolution tests of the PVP fiber mats show them to dissolve within 10 s, an improved dissolution profile over the pure drug. The Eudragit fibers show pH-dependent drug release profiles, with only very limited release at pH 2.0 but sustained release over approximately 8 h at pH 6.8. The Eudragit nanofibers have the potential to be developed as oral DDSs for localized drug release in the intestinal tract, whereas the PVP materials may find the application as buccal delivery systems or suppositories.

Item Type: Journal Item
Copyright Holders: 2013 Wiley Periodicals, Inc. and the American Pharmacists Association
ISSN: 1520-6017
Keywords: nanotechnology; solid solutions; solid dosage form; oral drug delivery; buccal delivery; site-specific delivery; electrospun nanofibers; mebeverine hydrochloride; povidone; Eudragit
Academic Unit/School: Other Departments > Other Departments
Item ID: 43759
Depositing User: Nicholas Chatterton
Date Deposited: 10 Aug 2015 09:56
Last Modified: 12 Oct 2016 02:16
URI: http://oro.open.ac.uk/id/eprint/43759
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