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Impact of age-related neuroglial cell responses on hippocampal deterioration

Ojo, Joseph O.; Rezaie, Payam; Gabbott, Paul and Stewart, Michael G. (2015). Impact of age-related neuroglial cell responses on hippocampal deterioration. Frontiers in Aging Neuroscience, 7, article no. 57.

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DOI (Digital Object Identifier) Link: https://doi.org/10.3389/fnagi.2015.00057
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Abstract

Aging is one of the greatest risk factors for the development of sporadic age-related neurodegenerative diseases and neuroinflammation is a common feature of this disease phenotype. In the immunoprivileged brain, neuroglial cells, which mediate neuroinflammatory responses, are influenced by the physiological factors in the microenvironment of the central nervous system (CNS). These physiological factors include but are not limited to cell-to-cell communication involving cell adhesion molecules, neuronal electrical activity and neurotransmitter and neuromodulator action. However, despite this dynamic control of neuroglial activity, in the healthy aged brain there is an alteration in the underlying neuroinflammatory response notably seen in the hippocampus, typified by astrocyte/microglia activation and increased pro-inflammatory cytokine production and signaling. These changes may occur without any overt concurrent pathology, however, they typically correlate with deteriorations in hippocamapal or cognitive function. In this review we examine two important phenomenons, firstly the relationship between age-related brain deterioration (focusing on hippocampal function) and underlying neuroglial response(s), and secondly how the latter affects molecular and cellular processes within the hippocampus that makes it vulnerable to age-related cognitive decline.

Item Type: Journal Item
Copyright Holders: 2015 Ojo, Rezaie, Gabbott and Stewart
ISSN: 1663-4365
Project Funding Details:
Funded Project NameProject IDFunding Body
MemStick201600EU FP7
Not SetBB/J021687/1BBSRC
Promemoria512012EU FP6
Extra Information: 16 pp.
Keywords: aging; microglia; astrocytes; neuroinflammation; hippocampus; cognition
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Health and Wellbeing PRA (Priority Research Area)
Item ID: 43619
Depositing User: Michael Stewart
Date Deposited: 06 Jul 2015 09:11
Last Modified: 16 Aug 2017 15:52
URI: http://oro.open.ac.uk/id/eprint/43619
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