Batty, Claire A.; Cauchi, Michael; Lourenco, Celia; Hunter, John O. and Turner, Claire
(2015).
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| DOI (Digital Object Identifier) Link: | https://doi.org/10.1371/journal.pone.0130301 |
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Abstract
Diagnosis of colorectal cancer is an invasive and expensive colonoscopy, which is usually carried out after a positive screening test. Unfortunately, existing screening tests lack specificity and sensitivity, hence many unnecessary colonoscopies are performed. Here we report on a potential new screening test for colorectal cancer based on the analysis of volatile organic compounds (VOCs) in the headspace of faecal samples. Faecal samples were obtained from subjects who had a positive faecal occult blood sample (FOBT). Subjects subsequently had colonoscopies performed to classify them into low risk (non-cancer) and high risk (colorectal cancer) groups. Volatile organic compounds were analysed by selected ion flow tube mass spectrometry (SIFT-MS) and then data were analysed using both univariate and multivariate statistical methods. Ions most likely from hydrogen sulphide, dimethyl sulphide and dimethyl disulphide are statistically significantly higher in samples from high risk rather than low risk subjects. Results using multivariate methods show that the test gives a correct classification of 75% with 78% specificity and 72% sensitivity on FOBT positive samples, offering a potentially effective alternative to FOBT.
| Item Type: | Journal Item | ||||||
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| Copyright Holders: | 2015 Batty et al. | ||||||
| ISSN: | 1932-6203 | ||||||
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| Keywords: | SIFT-MS VOCs; colorectal cancer; cancer screening; biomarkers | ||||||
| Academic Unit/School: | Faculty of Science, Technology, Engineering and Mathematics (STEM) > Physical Sciences Faculty of Science, Technology, Engineering and Mathematics (STEM) Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences |
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| Research Group: | Innovation, Knowledge & Development research centre (IKD) | ||||||
| Item ID: | 43601 | ||||||
| Depositing User: | Claire Turner | ||||||
| Date Deposited: | 02 Jul 2015 08:29 | ||||||
| Last Modified: | 23 May 2019 18:46 | ||||||
| URI: | http://oro.open.ac.uk/id/eprint/43601 | ||||||
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