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Use of the analysis of the volatile faecal metabolome in screening for colorectal cancer

Batty, Claire A.; Cauchi, Michael; Lourenco, Celia; Hunter, John O. and Turner, Claire (2015). Use of the analysis of the volatile faecal metabolome in screening for colorectal cancer. PLoS ONE, 10(6)

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DOI (Digital Object Identifier) Link: https://doi.org/10.1371/journal.pone.0130301
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Abstract

Diagnosis of colorectal cancer is an invasive and expensive colonoscopy, which is usually carried out after a positive screening test. Unfortunately, existing screening tests lack specificity and sensitivity, hence many unnecessary colonoscopies are performed. Here we report on a potential new screening test for colorectal cancer based on the analysis of volatile organic compounds (VOCs) in the headspace of faecal samples. Faecal samples were obtained from subjects who had a positive faecal occult blood sample (FOBT). Subjects subsequently had colonoscopies performed to classify them into low risk (non-cancer) and high risk (colorectal cancer) groups. Volatile organic compounds were analysed by selected ion flow tube mass spectrometry (SIFT-MS) and then data were analysed using both univariate and multivariate statistical methods. Ions most likely from hydrogen sulphide, dimethyl sulphide and dimethyl disulphide are statistically significantly higher in samples from high risk rather than low risk subjects. Results using multivariate methods show that the test gives a correct classification of 75% with 78% specificity and 72% sensitivity on FOBT positive samples, offering a potentially effective alternative to FOBT.

Item Type: Journal Item
Copyright Holders: 2015 Batty et al.
ISSN: 1932-6203
Project Funding Details:
Funded Project NameProject IDFunding Body
Fibre Optic Sensors for Point of Care Health Diagnostics (SC-13-001-CT)EP/L011395/1EPSRC (Engineering and Physical Sciences Research Council)
Keywords: SIFT-MS VOCs; colorectal cancer; cancer screening; biomarkers
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Innovation, Knowledge & Development research centre (IKD)
Item ID: 43601
Depositing User: Claire Turner
Date Deposited: 02 Jul 2015 08:29
Last Modified: 26 May 2017 12:19
URI: http://oro.open.ac.uk/id/eprint/43601
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