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Active screen plasma nitriding enhances cell attachment to polymer surfaces

Kaklamani, Georgia; Bowen, James; Mehrban, Nazia; Dong, Hanshan; Grover, Liam M. and Stamboulis, Artemis (2013). Active screen plasma nitriding enhances cell attachment to polymer surfaces. Applied Surface Science, 273 pp. 787–798.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.apsusc.2013.03.001
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Abstract

Active screen plasma nitriding (ASPN) is a well-established technique used for the surface modification of materials, the result of which is often a product with enhanced functional performance. Here we report the modification of the chemical and mechanical properties of ultra-high molecular weight poly(ethylene) (UHMWPE) using 80:20 (v/v) N2/H2 ASPN, followed by growth of 3T3 fibroblasts on the treated and untreated polymer surfaces. ASPN-treated UHMWPE showed extensive fibroblast attachment within 3 h of seeding, whereas fibroblasts did not successfully attach to untreated UHMWPE. Fibroblast coated surfaces were maintained for up to 28 days, monitoring their metabolic activity and morphology throughout. The chemical properties of the ASPN-treated UHMWPE surface were studied using X-ray photoelectron spectroscopy, revealing the presence of C N, C N, and C N chemical bonds. The elastic modulus, surface topography, and adhesion properties of the ASPN-treated UHMWPE surface were studied over 28 days during sample storage under ambient conditions and during immersion in two commonly used cell culture media.

Item Type: Journal Item
Copyright Holders: 2013 Elsevier B.V.
ISSN: 0169-4332
Keywords: active screen plasma nitriding; atomic force microscopy; fibroblast; interferometry; nanoindentation; X-ray photoelectron spectroscopy
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 43166
Depositing User: James Bowen
Date Deposited: 03 Jun 2015 16:01
Last Modified: 11 Nov 2016 05:49
URI: http://oro.open.ac.uk/id/eprint/43166
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