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In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

Truong, Vinh X.; Ablett, Matthew P.; Gilbert, Hamish T. J.; Bowen, James; Richardson, Stephen M.; Hoyland, Judith A. and Dove, Andrew P. (2014). In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering. Biomaterials Science, 2(2) pp. 167–175.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1039/c3bm60159e
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Abstract

A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly-(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5–60 min at 37 °C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.

Item Type: Journal Item
Copyright Holders: 2014 The Authors
ISSN: 2047-4849
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 43157
Depositing User: James Bowen
Date Deposited: 01 Jun 2015 09:32
Last Modified: 17 May 2017 04:59
URI: http://oro.open.ac.uk/id/eprint/43157
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