Truong, Vinh X.; Ablett, Matthew P.; Gilbert, Hamish T. J.; Bowen, James; Richardson, Stephen M.; Hoyland, Judith A. and Dove, Andrew P.
(2014).
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| DOI (Digital Object Identifier) Link: | https://doi.org/10.1039/c3bm60159e |
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| Google Scholar: | Look up in Google Scholar |
Abstract
A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly-(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5–60 min at 37 °C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.
| Item Type: | Journal Item |
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| Copyright Holders: | 2014 The Authors |
| ISSN: | 2047-4849 |
| Academic Unit/School: | Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation Faculty of Science, Technology, Engineering and Mathematics (STEM) |
| Item ID: | 43157 |
| Depositing User: | James Bowen |
| Date Deposited: | 01 Jun 2015 09:32 |
| Last Modified: | 21 Sep 2019 04:31 |
| URI: | http://oro.open.ac.uk/id/eprint/43157 |
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