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Truong, Vinh X.; Ablett, Matthew P.; Gilbert, Hamish T. J.; Bowen, James; Richardson, Stephen M.; Hoyland, Judith A. and Dove, Andrew P.
(2014).
DOI: https://doi.org/10.1039/c3bm60159e
Abstract
A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly-(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5–60 min at 37 °C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.
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About
- Item ORO ID
- 43157
- Item Type
- Journal Item
- ISSN
- 2047-4849
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Copyright Holders
- © 2014 The Authors
- Depositing User
- James Bowen