In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

Truong, Vinh X.; Ablett, Matthew P.; Gilbert, Hamish T. J.; Bowen, James; Richardson, Stephen M.; Hoyland, Judith A. and Dove, Andrew P. (2014). In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering. Biomaterials Science, 2(2) pp. 167–175.

DOI: https://doi.org/10.1039/c3bm60159e

Abstract

A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly-(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5–60 min at 37 °C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.

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