The Open UniversitySkip to content
 

Mechanical properties of alginate hydrogels manufactured using external gelation

Kaklamani, Georgia; Cheneler, David; Grover, Liam M.; Adams, Michael J. and Bowen, James (2014). Mechanical properties of alginate hydrogels manufactured using external gelation. Journal of the Mechanical Behavior of Biomedical Materials, 36 pp. 135–142.

Full text available as:
[img]
Preview
PDF (Accepted Manuscript) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (598kB) | Preview
DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.jmbbm.2014.04.013
Google Scholar: Look up in Google Scholar

Abstract

Alginate hydrogels are commonly used in biomedical applications such as scaffolds for tissue engineering, drug delivery, and as a medium for cell immobilization. Multivalent cations are often employed to create physical crosslinks between carboxyl and hydroxyl moieties on neighbouring polysaccharide chains, creating hydrogels with a range of mechanical properties. This work describes the manufacture and characterisation of sodium alginate hydrogels using the divalent cations Mg2+, Ca2+ and Sr2+ to promote gelation via non-covalent crosslinks. The gelation time and Young’s modulus are characterised as a function of cation and alginate concentrations. The implications of this work towards the use of environmental elasticity to control stem cell differentiation are discussed.

Item Type: Journal Item
Copyright Holders: 2014 Elsevier Ltd.
ISSN: 1878-0180
Keywords: alginate; calcium; cation; hydrogel; indentation; magnesium; modulus; strontium
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 43154
Depositing User: James Bowen
Date Deposited: 01 Jun 2015 09:08
Last Modified: 12 Nov 2016 18:16
URI: http://oro.open.ac.uk/id/eprint/43154
Share this page:

Altmetrics

Download history for this item

These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU