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Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation

Cheneler, David; Bowen, James and Kaklamani, Georgia (2014). Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation. Journal of Electrical Bioimpedance, 5(1) pp. 55–73.

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DOI (Digital Object Identifier) Link: https://doi.org/10.5617/jeb.869
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Abstract

Mechanotransduction is of fundamental importance in cell physiology, facilitating sensing in touch and hearing as well as tissue development and wound healing. This study used an impedance sensor to monitor the effective resistance and permittivity of artificial tissues, alginate hydrogel with encapsulated fibroblasts, which were kept viable through the use of a bespoke microfluidic system. The observed transient impedance responses upon the application of identical compressive normal loads differed between acellular hydrogels and hydrogels in which fibroblasts were encapsulated. These differences resulted from changes in the conductivity and permeability of the hydrogel due to the presence of the encapsulated fibroblasts, and transient changes in ion concentrations due to mechanotransduction effects.

Item Type: Journal Item
ISSN: 1891-5469
Project Funding Details:
Funded Project NameProject IDFunding Body
FP7 programme (NANOBIOTOUCH Project)FP7-NMP-228844EU
Not SetNot SetEuropean Regional Development Fund (ERDF)
Keywords: bioimpedance; mechanotransduction; restitution; cells; artificial skin; tissue engineering
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Related URLs:
Item ID: 43151
Depositing User: James Bowen
Date Deposited: 27 May 2015 15:00
Last Modified: 16 Nov 2016 07:07
URI: http://oro.open.ac.uk/id/eprint/43151
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