Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation

Cheneler, David; Bowen, James and Kaklamani, Georgia (2014). Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation. Journal of Electrical Bioimpedance, 5(1) pp. 55–73.

DOI: https://doi.org/10.5617/jeb.869

Abstract

Mechanotransduction is of fundamental importance in cell physiology, facilitating sensing in touch and hearing as well as tissue development and wound healing. This study used an impedance sensor to monitor the effective resistance and permittivity of artificial tissues, alginate hydrogel with encapsulated fibroblasts, which were kept viable through the use of a bespoke microfluidic system. The observed transient impedance responses upon the application of identical compressive normal loads differed between acellular hydrogels and hydrogels in which fibroblasts were encapsulated. These differences resulted from changes in the conductivity and permeability of the hydrogel due to the presence of the encapsulated fibroblasts, and transient changes in ion concentrations due to mechanotransduction effects.

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About

• Item ORO ID
• 43151
• Item Type
• Journal Item
• ISSN
• 1891-5469
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  FP7 programme (NANOBIOTOUCH Project)	FP7-NMP-228844	EU
  Not Set	Not Set	European Regional Development Fund (ERDF)

• Keywords
• bioimpedance; mechanotransduction; restitution; cells; artificial skin; tissue engineering
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Related URLs
• • https://www.journals.uio.no/index.php/bi...(Author Website)
• Depositing User
• James Bowen