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Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces

Smith, Alan M.; Paxton, Jennifer Z.; Hung, Yi-Pei; Hadley, Martin J.; Bowen, James; Williams, Richard L. and Grover, Liam M. (2015). Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces. Materials Science and Engineering: C, 48(1) pp. 5–10.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.msec.2014.11.006
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Abstract

Calcium phosphate coatings have been applied to the surface of metallic prostheses to mediate hard and soft tissue attachment for more than 40 years. Most coatings are formed of high purity hydroxyapatite, and coating methods are often designed to produce highly crystalline surfaces. It is likely however, that coatings of lower crystallinity can facilitate more rapid tissue attachment since the surface will exhibit a higher specific surface area and will be considerably more reactive than a comparable highly crystalline surface. Here we test this hypothesis by growing a population of MC3T3 osteoblast-like cells on the surface of two types of hip prosthesis with similar composition, but with differing crystallinity. The surfaces with lower crystallinity facilitated more rapid cell attachment and increased proliferation rate, despite having a less heterogeneous surface topography. This work highlights that the influence of the crystallinity of HA at the nano-scale is dominant over macroscale topography for cell adhesion and growth. Furthermore, crystallinity could be easily adjusted by without compromising coating purity. These findings could facilitate designing novel coated calcium phosphate surfaces that more rapidly bond tissue following implantation.

Item Type: Journal Item
Copyright Holders: 2014 Elsevier Ltd.
ISSN: 0928-4931
Keywords: prosthesis; calcium phosphate; hydroxyapatite; coating; crystallinity
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Engineering and Innovation
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 43150
Depositing User: James Bowen
Date Deposited: 26 May 2015 09:46
Last Modified: 17 Nov 2016 21:52
URI: http://oro.open.ac.uk/id/eprint/43150
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