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Nucleotides and oligonucleotides: mononucleotides

Narukulla, Raman and Xu, Yao-Zhong (2015). Nucleotides and oligonucleotides: mononucleotides. In: Allen, David; Tebby, John C. and Loakes, David eds. Organophosphorus Chemistry, Volume 44. Cambridge: The Royal Society of Chemistry, pp. 170–192.

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This chapter covers selected papers published in 2013 on chemical synthesis and medicinal application of modified nucleotides and oligonucleotides. Nucleotides are the building blocks of nucleic acids and play fundamental roles in biological processes. Novel synthetic methods for modified nucleotides are continuously developed and their biological potentials extensively explored. As in the previous year the chemical synthesis and medicinal exploration of modified nucleoside monophosphates and triphosphates are divided into sections relating to the nucleobase and sugar. This chapter also reviews research developments on various forms of modified nucleotides, including phosphoramidites, phosphoramidates and phosphonates, triphosphates and oligomers.

Item Type: Book Section
Copyright Holders: 2015 The Royal Society of Chemistry
ISBN: 1-78262-111-3, 978-1-78262-111-9
Keywords: nucleoside monophosphates
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 42724
Depositing User: Yao Xu
Date Deposited: 12 May 2015 08:49
Last Modified: 07 Dec 2018 18:27
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