Nucleotides and oligonucleotides: mononucleotides

Narukulla, Raman and Xu, Yao-Zhong (2015). Nucleotides and oligonucleotides: mononucleotides. In: Allen, David; Tebby, John C. and Loakes, David eds. Organophosphorus Chemistry, Volume 44. Cambridge: The Royal Society of Chemistry, pp. 170–192.

DOI: https://doi.org/10.1039/9781782622765-00170

Abstract

This chapter covers selected papers published in 2013 on chemical synthesis and medicinal application of modified nucleotides and oligonucleotides. Nucleotides are the building blocks of nucleic acids and play fundamental roles in biological processes. Novel synthetic methods for modified nucleotides are continuously developed and their biological potentials extensively explored. As in the previous year the chemical synthesis and medicinal exploration of modified nucleoside monophosphates and triphosphates are divided into sections relating to the nucleobase and sugar. This chapter also reviews research developments on various forms of modified nucleotides, including phosphoramidites, phosphoramidates and phosphonates, triphosphates and oligomers.

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About

• Item ORO ID
• 42724
• Item Type
• Book Section
• ISBN
• 1-78262-111-3, 978-1-78262-111-9
• Keywords
• nucleoside monophosphates
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Research Group
• Chemistry and Materials Research Group
• Copyright Holders
• © 2015 The Royal Society of Chemistry
• Depositing User
• Yao Xu