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5-iodo-4-thio-2′-deoxyuridine: synthesis, structure, and cytotoxic activity

Zhang, Xiao-Hui; Yin, Hong-Yan; Trigiante, Joseph; Brem, Reto; Karran, Peter; Pitak, Mateusz B.; Coles, Simon J. and Xu, Yao-Zhong (2015). 5-iodo-4-thio-2′-deoxyuridine: synthesis, structure, and cytotoxic activity. Chemistry Letters, 44(2) pp. 147–149.

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The novel nucleoside 5-iodo-4-thio-2′-deoxyuridine (4) was synthesized and fully characterized by IR, NMR, and MS. Its structure was determined by single-crystal X-ray diffraction. Compound 4 absorbs strongly at 346 nm and is minimally toxic to human tumour cells, but its cytotoxicity is substantially enhanced by low dose UVA radiation. The combined use of 4 and UVA offers a promising route to selectively and effectively kill proliferating cells.

Item Type: Journal Item
Copyright Holders: 2015 Chemical Society of Japan
ISSN: 1348-0715
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 42190
Depositing User: Yao Xu
Date Deposited: 26 Feb 2015 11:03
Last Modified: 07 Dec 2018 14:39
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